Mojca zuniga biography

  • His father was Karamchand Uttamchand Gandhi
  • Mojca Kovač Šebart – Faculty of

    • Biography on stephen wunderlist

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    Vol 19 (2025)

    Table of Contents

    Articles

    Decolonizing the Queer Project of Aotearoa New Zealand: Weaving Takatāpui Identity Into Queer SpacesABSTRACTPDF
    Elena Maydell 19 pgs.
    Research Practices in Comparative Communication Research: Visibility, Topical and Geographical Disparities, and their Longitudinal PatternsABSTRACTPDF
    Fabienne Lind, Hyunjin Song, Hajo G. B

    Promiscuous gene expression

    Promiscuous gene expression (PGE), formerly referred to as ectopic expression, is a process specific to the thymus that plays a pivotal role in the establishment of central tolerance. This phenomenon enables generation of self-antigens, so called tissue-restricted antigens (TRAs), which are in the body expressed only by one or few specific tissues (antigens rank among TRAs if they are expressed by less than five tissues from the sixty tested ). These antigens are represented for example by insulin from the pancreas or defensins from the gastrointestinal tract.Antigen-presenting cells (APCs) of the thymus, namely medullary thymic epithelial cells (mTECs), dendritic cells (DCs) and B cells are capable to present peptides derived from TRAs to developing T cells (thymus is the major origin of T cell development) and hereby test, whether their T cell receptors (TCRs) engage self entities and therefore their occurrence in the body can potentially lead to the development of autoimmune disease. In that case, thymic APCs either induce apoptosis in these autoreactive T cells (negative selection) or they deviate them to become T regulatory cells (Treg selection), which suppress self-reactive T cells in the body that escaped negative selection in the thymus. Thus, PGE is crucial for tissues protection against autoimmunity.

    Characteristics of PGE in distinct cell types

    The usual level of gene expression in the peripheral tissues (e.g. spleen, kidney, liver etc.) reaches about 60% of the mouse coding genome. Some peripheral tissues, including lungs, brain and testis, reveal the repertoire of expressed genes about 10% broader. Importantly, PGE in the thymus, which is mediated by unique subset of epithelial cells called mTECs, triggers expression of vast majority of the genes from the whole genome (~85%). Such a broad repertoire of expressed genes wasn't shown in any other tissue of the

    Articles

  • Development and testing of relative risk-based health messages for electronic cigarette products

    Health messages on e-cigarette packs emphasise nicotine addiction or harms using similar wording to warnings on cigarette packs. These may not be appropriate for e-cigarettes which constitute a reduced risk al...

    Authors: Catherine Kimber, Sharon Cox, Daniel Frings, Ian P. Albery and Lynne Dawkins

    Citation:Harm Reduction Journal 2021 18:96

    Content type: MethodologyPublished on: 8 September 2021

  • Implementation of buprenorphine services in NYC syringe services programs: a qualitative process evaluation

    Syringe services programs (SSPs) hold promise for providing buprenorphine treatment access to people with opioid use disorder (OUD) who are reluctant to seek care elsewhere. In 2017, the New York City Departme...

    Authors: Andrea Jakubowski, Caroline Rath, Alex Harocopos, Monique Wright, Alice Welch, Jessica Kattan, Czarina Navos Behrends, Teresa Lopez-Castro and Aaron D. Fox

    Citation:Harm Reduction Journal 2022 19:75

    Content type: ResearchPublished on: 10 July 2022

  • New psychoactive substances in Eurasia: a qualitative study of people who use drugs and harm reduction services in six countries

    This study examines the use of new psychoactive substances (NPS) and the harm reduction response in six Eurasian countries: Belarus, Moldova, Serbia, Kazakhstan, Kyrgyzstan, and Georgia. The aim is to identify...

    Authors: Eliza Kurcevič and Rick Lines

    Citation:Harm Reduction Journal 2020 17:94

    Content type: ResearchPublished on: 30 November 2020

  • Older adult drug overdose: an application of latent class analysis to identify prevention opportunities

    Older adult overdose death rates have increased significantly in recent years. However, research for prevention of drug overdose death specific to older adults is limited. Our objective is to identify profiles...

    Authors: Maryann Mason, Kaveet Pandya and Alexander Lundberg

    Citation:Harm Re

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